国际口腔医学杂志 ›› 2017, Vol. 44 ›› Issue (1): 103-107.doi: 10.7518/gjkq.2017.01.021

• ·综述· • 上一篇    下一篇

白假丝酵母菌与龋病的相关性及其致龋机制

刘诗雨,何金枝,李明云   

  1. 口腔疾病研究国家重点实验室 华西口腔医院(四川大学) 成都 610041
  • 收稿日期:2016-03-19 出版日期:2017-01-01 发布日期:2017-01-01
  • 通讯作者: 李明云,讲师,博士,Email:limingyun@scu.edu.cn
  • 作者简介:刘诗雨,硕士,Email:1203383220@qq.com
  • 基金资助:
    国家自然科学基金(81400501); 口腔疾病研究国家重点实验室专项经费(SKLOD201525); 四川大学大学生创新训练计划(201510610309)

Saccharomyces albicans: its dental caries correlation and mechanism

Liu Shiyu, He Jinzhi, Li Mingyun.   

  1. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2016-03-19 Online:2017-01-01 Published:2017-01-01

摘要: 白假丝酵母菌是一种革兰阳性真菌微生物,广泛存在于健康人的上呼吸道、肠道和阴道中,当其与宿主处于共生状态时不会引起疾病,反之则由酵母相转化为菌丝相,导致口腔黏膜感染,引起口腔龋坏病变。在龋病患者的口腔生物膜上,变异链球菌和白假丝酵母菌之间可能存在某种互动关系并介导龋病的发展。白假丝酵母菌可与格氏链球菌紧密地黏附在一起,即格氏链球菌细胞壁表面的多糖是白假丝酵母菌黏附的受体之一。格氏链球菌可缓解群体感应机制对白假丝酵母菌菌丝相形成和生物膜生长的抑制作用,从而增加菌斑生物膜的量。本文就白假丝酵母菌,白假丝酵母菌与龋病的相关性,白假丝酵母菌与变异链球菌、格氏链球菌和其他口腔细菌相互作用参与龋病的发生发展的可能机制等研究进展作一综述,旨在为以后的临床研究提供思路和参考。

关键词: 白假丝酵母菌, 龋病, 变异链球菌, 格氏链球菌

Abstract: Saccharomyces albicans(S. albicans) is a Gram-positive fungus and widely exists in the upper respiratory tract, intestinal canal, and vagina of healthy people. S. albicans does not cause diseases in a state of symbiosis with the host. The ability of S. albicans to switch its morphotype from yeast to hyphal forms contributes to its pathogenesis and leads to oral mucosa infection and dental caries. In oral biofilms of caries-affected people, an interaction may exist between S. albicans and Streptococcus mutans(S. mutans) leading to the development of dental caries. S. albicans tends to adhere tightly to Streptococcus gordonii(S. gordonii), that is, a polysaccharide existing on the surface of the cell wall of S. gordonii is one of the adhesion receptors of S. albicans. S. gordonii can alleviate the inhibition effect of quorum-sensing mechanism on hyphae formation and biofilm development of S. albicans, thereby increasing the biomass. This review focused on S. albicans, the correlation of S. albicansand dental caries, and the research progress on the possible specific mechanism involved in the occurrence and development of dental caries caused by the interactions of S. albicans, together with S. mutans, S. gordonii, and other oral bacteria. This study aims to provide ideas and references for future clinical research.

Key words: Saccharomyces albicans, dental ceries, Streptococcus mutans, Streptococcus gordonii

中图分类号: 

  • R780.2
[1] Metwalli KH, Khan SA, Krom BP, et al. Strepto-coccus mutans , Candida albicans , and the human mouth: a sticky situation[J]. PLoS Pathog, 2013, 9 (10):e1003616.
[2] Dewhirst FE, Chen T, Izard J, et al. The human oral microbiome[J]. J Bacteriol, 2010, 192(19):5002- 5017.
[3] Costalonga M, Herzberg MC. The oral microbiome and the immunobiology of periodontal disease and caries[J]. Immunol Lett, 2014, 162(2Pt A):22-38.
[4] He J, Li Y, Cao Y, et al. The oral microbiome div-ersity and its relation to human diseases[J]. Folia Microbiol, 2015, 60(1):69-80.
[5] Warinner C, Rodrigues JF, Vyas R, et al. Pathogens and host immunity in the ancient human oral cavity [J]. Nat Genet, 2014, 46(4):336-344.
[6] Han YW, Wang X. Mobile microbiome: oral bacteria in extra-oral infections and inflammation[J]. J Dent Res, 2013, 92(6):485-491.
[7] Umemura K, Wada K. Roles of oral bacteria in car-diovascular diseases—from molecular mechanisms to clinical cases: preface[J]. J Pharmacol Sci, 2010, 113(2):101-102.
[8] Astafurov K, Elhawy E, Ren L, et al. Oral micro-biome link to neurodegeneration in glaucoma[J]. PLoS One, 2014, 9(9):e104416.
[9] Selwitz RH, Ismail AI, Pitts NB. Dental caries[J]. Lancet, 2007, 369(9555):51-59.
[10] Lund AE. Bacterium, fungus may lead to early childhood caries[J]. J American Dent Asso, 2014, 145(5):426-427.
[11] Cavalcanti YW, Morse DJ, da Silva WJ, et al. Virulence and pathogenicity of Candida albicans is enhanced in biofilms containing oral bacteria[J]. Biofouling, 2015, 31(1):27-38.
[12] Kraneveld EA, Buijs MJ, Bonder MJ, et al. The relation between oral Candida load and bacterial microbiome profiles in Dutch older adults[J]. PLoS One, 2012, 7(8):e42770.
[13] Sztajer H, Szafranski SP, Tomasch J, et al. Cross-feeding and interkingdom communication in dual-species biofilms of Streptococcus mutans and Candida albicans [J]. ISME J, 2014, 8(11):2256-2271.
[14] Falsetta ML, Klein MI, Colonne PM, et al. Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo [J]. Infect Immun, 2014, 82(5):1968- 1981.
[15] 周学东, 肖丽英, 肖晓蓉. 实用口腔微生物学与技术[M]. 北京: 人民卫生出版社, 2009:154. Zhou XD, Xiao LY, Xiao XR. Applied oral micro-biology and technique[M]. Beijing: People’s Me-dical Publishing House, 2009:154.
[16] Kim J, Sudbery P. Candida albicans , a major human fungal pathogen[J]. J Microbiol, 2011, 49(2):171- 177.
[17] Nikawa H, Yamashiro H, Makihira S, et al. In vitro cariogenic potential of Candida albicans [J]. Mycoses, 2003, 46(11/12):471-478.
[18] Klinke T, Guggenheim B, Klimm W, et al. Dental caries in rats associated with Candida albicans [J]. Caries Res, 2011, 45(2):100-106.
[19] Ghasempour M, Sefidgar SA, Eyzadian H, et al. Prevalence of Candida albicans in dental plaque and caries lesion of early childhood caries(ECC) ac-cording to sampling site[J]. Caspian J Intern Med, 2011, 2(4):304-308.
[20] de Carvalho FG, Silva DS, Hebling J, et al. Presence of mutans streptococci and Candida spp. in dental plaque/dentine of carious teeth and early childhood caries[J]. Arch Oral Biol, 2006, 51(11):1024-1028.
[21] Akdeniz BG, Koparal E, Sen BH, et al. Prevalence of Candida albicans in oral cavities and root canals of children[J]. ASDC J Dent Child, 2002, 69(3):289- 292.
[22] Barbieri DdS’AV, Vicente VA, Fraiz FC, et al. Analysis of the in vitro adherence of Streptococcus mutans and Candida albicans [J]. Braz J Microbiol, 2007, 38(4):624-663.
[23] Jarosz LM, Deng DM, van der Mei HC, et al. Stre-ptococcus mutans competence-stimulating peptide inhibits Candida albicans hypha formation[J]. Eukaryotic Cell, 2009, 8(11):1658-1664.
[24] Bagg J, Silverwood RW. Coagglutination reactions between Candida albicans and oral bacteria[J]. J Med Microbiol, 1986, 22(2):165-169.
[25] Branting C, Sund ML, Linder LE. The influence of Streptococcus mutans on adhesion of Candida albi - cans to acrylic surfaces in vitro [J]. Arch Oral Biol, 1989, 34(5):347-353.
[26] Gregoire S, Xiao J, Silva BB, et al. Role of glu-cosyltransferase B in interactions of Candida albicans with Streptococcus mutans and with an experimental pellicle on hydroxyapatite surfaces[J]. Appl Environ Microbiol, 2011, 77(18):6357-6367.
[27] Nyvad B, Kilian M. Comparison of the initial streptococcal microflora on dental enamel in caries-active and in caries-inactive individuals[J]. Caries Res, 1990, 24(4):267-272.
[28] Scannapieco FA, Solomon L, Wadenya RO. Emer-gence in human dental plaque and host distribution of amylase-binding streptococci[J]. J Dent Res, 1994, 73(10):1627-1635.
[29] Gilbert K, Joseph R, Vo A, et al. Children with severe early childhood caries: streptococci genetic strains within carious and white spot lesions[J]. J Oral Microbiol, 2014, doi:10.3402/jom.v6.25805.
[30] Tanzer JM, Thompson AM, Grant LP, et al. Stre-ptococcus gordonii’s sequenced strain CH1 glu-cosyltransferase determines persistent but not initial colonization of teeth of rats[J]. Arch Oral Biol, 2008, 53(2):133-140.
[31] Marchant S, Brailsford SR, Twomey AC, et al. The predominant microflora of nursing caries lesions[J]. Caries Res, 2001, 35(6):397-406.
[32] Jenkinson HF, Lala HC, Shepherd MG. Coaggrega-tion of Streptococcus sanguis and other streptococci with Candida albicans [J]. Infect Immun, 1990, 58 (5):1429-1436.
[33] Holmes AR, Cannon RD, Jenkinson HF. Interactions of Candida albicans with bacteria and salivary mo-lecules in oral biofilms[J]. J Ind Microbiol, 1995, 15 (3):208-213.
[34] Holmes AR, Gopal PK, Jenkinson HF. Adherence of Candida albicans to a cell surface polysaccharide receptor on Streptococcus gordonii [J]. Infect Immun, 1995, 63(5):1827-1834.
[35] Ricker A, Vickerman M, Dongari-Bagtzoglou A. Streptococcus gordonii glucosyltransferase promotes biofilm interactions with Candida albicans [J]. J Oral Microbiol, 2014, doi:10.3402/jom.v6.23419.
[36] Silverman RJ, Nobbs AH, Vickerman MM, et al. Interaction of Candida albicans cell wall Als3 protein with Streptococcus gordonii SspB adhesin promotes development of mixed-species communi-ties[J]. Infect Immun, 2010, 78(11):4644-4652.
[37] Bamford CV, d’Mello A, Nobbs AH, et al. Strep-tococcus gordonii modulates Candida albicans biofilm formation through intergeneric communication[J]. Infect Immun, 2009, 77(9):3696-3704.
[38] Orsi CF, Sabia C, Ardizzoni A, et al. Inhibitory effects of different lactobacilli on Candida albicans hyphal formation and biofilm development[J]. J Biol Regul Homeost Agents, 2014, 28(4):743-752.
[39] Vilela SF, Barbosa JO, Rossoni RD, et al. Lac-tobacillus acidophilus ATCC 4356 inhibits biofilm formation by C.albicans and attenuates the expe-rimental candidiasis in Galleria mellonella[J]. Viru-lence, 2015, 6(1):29-39.
[40] Ceresa C, Tessarolo F, Caola I, et al. Inhibition of Candida albicans adhesion on medical-grade silicone by a Lactobacillus -derived biosurfactant[J]. J Appl Microbiol, 2015, 118(5):1116-1125.
(本文采编 王晴)
[1] 丁杰, 宋光泰. 微创技术在儿童龋病治疗中的应用[J]. 国际口腔医学杂志, 2018, 45(4): 473-479.
[2] 周羽洁, 任彪, 程磊, 周学东. 白假丝酵母菌在义齿性口炎中的相关研究[J]. 国际口腔医学杂志, 2017, 44(4): 477-483.
[3] 盖阔, 郝丽英, 蒋丽. 应用原子力显微镜对口腔变异链球菌黏附机制的研究[J]. 国际口腔医学杂志, 2017, 44(3): 320-324.
[4] 王玉霞,周学东,李明云. 韦荣球菌与龋病和链球菌间的关系[J]. 国际口腔医学杂志, 2017, 44(2): 195-199.
[5] 郑黎薇, 邹静, 夏斌, 刘英群, 黄洋, 赵今. 儿童乳磨牙金属预成冠的修复治疗[J]. 国际口腔医学杂志, 2017, 44(2): 125-129.
[6] 刘琨,侯本祥. 粪肠球菌和变异链球菌脂磷壁酸的生物学活性[J]. 国际口腔医学杂志, 2017, 44(1): 118-124.
[7] 周双双 郑欣 周学东 徐欣. 菌斑生物膜产碱代谢与龋病[J]. 国际口腔医学杂志, 2016, 43(5): 573-577.
[8] 张鹰 李明勇 霍丽 孟媛. 变异链球菌自诱导物2信号分子的体外合成与活性检测[J]. 国际口腔医学杂志, 2016, 43(5): 519-523.
[9] 王一舟,张雅琪,牛雪微,张志民. 变异链球菌groE操纵子及其表达与调控[J]. 国际口腔医学杂志, 2016, 43(3): 348-351.
[10] 赵兴福,江山,黄晓晶,闫福华. 变异链球菌临床株表面相关蛋白表达差异的初步分析[J]. 国际口腔医学杂志, 2016, 43(3): 273-277.
[11] 石晶,闫征斌,侯景秋,彭惠. 无托槽隐形矫治与传统固定矫治对牙周变异链球菌和牙龈卟啉单胞菌的影响[J]. 国际口腔医学杂志, 2016, 43(2): 151-154.
[12] 冯汝舟 刘娟 吕长海. 氟化物在儿童和青少年龋病防治中的应用[J]. 国际口腔医学杂志, 2016, 43(1): 118-.
[13] 刘奕1 费伟1 王丽娜2 张思宇3 王艳君1 吴红崑4. 十肽对变异链球菌生物膜生长和结构影响的实验研究[J]. 国际口腔医学杂志, 2015, 42(4): 401-405.
[14] 宋颖 邹玲. 胶原层粘连结合蛋白的结构和功能及防治策略[J]. 国际口腔医学杂志, 2015, 42(4): 466-470.
[15] 方力 刘源 杨燃 邹静. 树脂充填前后唾液中变异链球菌的变化[J]. 国际口腔医学杂志, 2015, 42(1): 28-30.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!